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In people who are overweight. Diabetes develops when the body proves unable to burn sugar and the unused sugar builds up in the bloodstream. Metformin decreases the amount of glucose you absorb from your food and the amount of glucose made by your liver. Metformin increases the sensitivity of muscle cells to insulin. Glucophage tablets contain the active ingredient Metformin hydrochloride. Insulin would normally make the cells remove sugar from the blood hence in type 2 diabetes the pancreas does not produce sufficient insulin and the cells of the body are resistant to the low levels of insulin circulating in the blood. Metformin decreases the amount of sugar in the blood.